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. 2018 Sep 20;37:233. doi: 10.1186/s13046-018-0873-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — NPC-PDX drug screening. (a-f) PDX-Bone (NPC13-F4 corresponds to patient no.13 derived bone metastatic NPC tumor was transplanted in NOD/SCID mice at 4th passage); (a, b) Mice gross tumor, (c) tumor volume, (d) tumor weight, (e) mice body weight change, and (f) cyclin D1 IHC and EBER staining in control (DMSO) and GEM and PAL treatment. (g-h) PDX-LN (NPC02-F11 corresponds to patient no.2 derived lymph node metastatic NPC tumor was transplanted in NOD/SCID mice at 11th passage), (g) tumor volume, (h) tumor weight. Abbreviation: GSK, GSK126; DEC, decitabine; GEM, gemcitabine; PAL, palbociclib. (Raw data was provided in Additional file 17: Table S9 A-D)