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. Author manuscript; available in PMC: 2019 Jul 20.
Published in final edited form as: Adv Drug Deliv Rev. 2018 Jul 20;130:58–72. doi: 10.1016/j.addr.2018.07.008

Figure 7.

Figure 7.

Inhibition of PKM2 methylation using a competitive PKM2 peptide reduces tumor lung metastasis in vivo. Bioluminescence at indicated times was measured in the lung when mice (n=6) were treated with unimolecular NPs loaded with methyl PKM2 peptide (UMNP-methyl-peptide) or unimolecular NPs loaded with non-methyl PKM2 peptide (UMNP-nonmethyl-peptide). Representative bioluminescence images of mice after four-week treatment with UMNP-methyl-peptide (n=4) or UMNP-nonmethyl-peptide (n=5) via retroorbital injection at the indicated times after tumor introduction. The color scale depicts the photon flux (photons per second) emitted from the xenografted mice. Reproduced with permission from Ref. [70].