. Author manuscript; available in PMC: 2019 Jul 20.

Published in final edited form as: Adv Drug Deliv Rev. 2018 Jul 20;130:58–72. doi: 10.1016/j.addr.2018.07.008

Table 1:

Representative polymeric unimolecular NPs for biomedical applications.

	Chemical composition	Therapeutic payloads	Imaging Probes	Reference
Water-dispersible unimolecular micelles	H40-PLA-PEG	DOX	-	62
	H40-PCL-PEG	Resveratrol	-	151
	PAMAM-PLA-PEG	DOX	⁶⁴Cu (PET)	115
	PAMAM-PVL-PEG	TDP-A	Cy5 (optical imaging)	120
	PGA-g-(PCL-b-PEG)	DOX	-	129
	POSS-(G3-PLLA-b-PEO-COOH)₈	DOX	-	133
	β-CD-P(DPA-co-OEGMA)	DOX + BBT-2FT	-	156
	H40-BPLP-PEG	DOX	BPLP (self-fluorescent)	183
	H-P(CPTM-co-DOTA(Gd))-P(OEGMA-co-GPMA)	CPT	DOTA/Gd (MRI)	196
	β-CD-(PCL-PAEMA-PPEGMA)₂₁/AuNPs	DOX	AuNPs (CT imaging)	197
Water-soluble unimolecular nanoparticles	PAMAM-PAsp-PEG	Carboplatin	Cy5 (optical imaging)	136
	PAMAM-PGA-PEG	DACHPt	-	71
	PFNBr-PDMAEMA	siRNA	-	72
	H40-P(Asp-AED-ICA)-PEG	siRNA	Cy5 (optical imaging)	137
	PAMAM-PAsp(DET-Aco-r-Im)-PEG	Peptide	-	70