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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Brain Behav Immun. 2018 Jul 25;73:34–40. doi: 10.1016/j.bbi.2018.07.020

Figure 3. Dural lymphatic vasculature and meningeal Aβ immunoreactivity in AD subjects.

Figure 3.

A. Detection of Aβ immunoreactivity with 6E10 and 4G8 clones, and Aβ aggregates with the congophilic X-34 dye in frontal cortex (top), within dural tissue (middle), and in meningeal blood vessels (bottom, arrowhead). B. Representative Type 1 (left) and Type 2 (right) lymphatic vessel (arrows). Sequential slices stained with PDPN, 6E10, 4G8 and X-34 shows that co-localization between PDPN and the 6E10 in some vessels. PDPN co-localization with 4G8 immunoreactivity or with X-34 labeling was not observed. Scale bars in frontal cortex micrographs represent 20 um and scale bars in other micrographs represent 50 μm.