Table 1.

Reaction conditions and yields of vinblastine in synthesis. (VLB = vinblastine; CTR = catharanthine; VDL = vindoline).

Starting materials and reagents for synthesis reaction	Chemicals and reagents added during synthesis	Reaction temp (°C)	Reaction time (h)	Final pH	Yield of VLB based on % of initial concentrations of CTR          VDL
100 mg embonic acid precipitate + 10 mL 0.1 M HCL + 10 mL 0.1 M citric acid solution + 10 mL dichloromethane	10 mL of 30% H2O2 + 10 mL of 10% NaOCl + 10-20 mL of 0.1% solution of NaBH4 in methanol	0 - (-5)	0	1.8	0	0
			3	4.5	2	1.5
			3.5	6.0	12	7.5
			4	7.3	18	10
			4.5	8.3	20	14.5
			5	9.5	19	14.5