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Synthesis of target compounds.
Reagents and conditions: a) aminoguanidine, γ-butyrolactone, Py, reflux, 10 h; b) ethyl acetoacetate, acetic acid, reflux, 30 h, c) methanolic ammonia, room temperature, 24 h; d) POCl3, reflux, 3 h; e) R1NH2, iPrOH, 50°C, 3 h; f) furan-2-ylmethanethiol, NaH, DMF, 50°C, 0.5 h; g) HCHO, R2R3NH, AcOH, 50°C, 4 h.
