Table 1.
Name, abbreviation, P-value threshold, and original publication for each phenotype included in this study.
| Phenotype | Abbreviation | P thresholda | Publication |
|---|---|---|---|
| Immune phenotypes | |||
| Any diseases | ALL | 5 × 10−8 | Ferreira et al., 2017 |
| Asthma | ATH | 5 × 10−8 | Demenais et al., 2018 |
| Crohn’s disease | CD | 5 × 10−8 | de Lange et al., 2017 |
| Eosinophil counts | EO | 8.31 × 10−9 | Astle et al., 2016 |
| Granulocyte count | GRAN | 8.31 × 10−9 | Astle et al., 2016 |
| Inflammatory bowel disease | IBD | 5 × 10−8 | de Lange et al., 2017 |
| Lymphocyte counts | LYMPH | 8.31 × 10−9 | Astle et al., 2016 |
| Monocyte count | MONO | 8.31 × 10−9 | Astle et al., 2016 |
| Myeloid white cell count | MWBC | 8.31 × 10−9 | Astle et al., 2016 |
| Neutrophil count | NEUT | 8.31 × 10−9 | Astle et al., 2016 |
| Ulcerative colitis | UC | 5 × 10−8 | de Lange et al., 2017 |
| White blood cell count | WBC | 8.31 × 10−9 | Astle et al., 2016 |
| Growth phenotypes | |||
| Birth length | BL | 1 × 10−5 | van der Valk et al., 2014 |
| Bone mineral density | BMD | 5 × 10−8 | Medina-Gomez et al., 2017 |
| Childhood body mass index | BMI | 5 × 10−8 | Felix et al., 2015 |
| Birthweight | BW | 5 × 10−8 | Horikoshi et al., 2016 |
| Gestational weight gain (maternal) | GWGM | 1 × 10−5 | Warrington et al., 2018 |
| Gestational weight gain (offspring) | GWGO | 1 × 10−5 | Warrington et al., 2018 |
| Childhood head circumference | HC | 1 × 10−5 | Taal et al., 2012 |
| Height | HEIGHT | 5 × 10−8 | Wood et al., 2014 |
| Leptin levels | LEP | 1 × 10−5 | Kilpeläinen et al., 2016 |
| Total-body lean mass | LM | 1 × 10−5 | Medina-Gomez et al., 2017 |
| Birthweight (maternal) | MBW | 5 × 10−8 | Beaumont et al., 2018 |
| Childhood obesity | OBESITY | 5 × 10−8 | Bradfield et al., 2012 |
| Pubertal growth | PG | 5 × 10−8 | Cousminer et al., 2013 |
aThe significance threshold used for the GWAS for each phenotype, which was normally from the original study, but was lowered to 1 × 10−5 when the number of GWS SNPs was too low.