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. 2017 Oct 26;12(3):195–203. doi: 10.1080/19336918.2017.1345413

Figure 4.

Figure 4.

Molecular model depicting UNC-53 mediated regulation of UNC-5 in Rac GTPase dependent and independent pathways required for proper DTC migration: The genetic data supports UNC-53 functioning in Rac GTPase dependent and independent pathways for proper DTC migration by regulating the activity of UNC-5 receptor. We propose that UNC-53 primarily regulate UNC-5 activity by 2 pathways, first by negatively regulating CED-10 and MIG-2 mediated signaling and second pathway includes ABL-1 and most probably ABI-1.