TABLE-1.
Patient Characteristics According to Cardiotoxicity Among Patients Ages 18–80+ With Breast Cancer (N=16456).
| Cardiotoxicity | |||
|---|---|---|---|
| Patient Characteristic | Total; N | Yes; N (%) | P |
| All Patients | 16456 | 692 (4.2) | <0.001 |
| Age, years | <0.001 | ||
| <35 | 426 | 9 (2.1) | |
| 36–49 | 4116 | 121 (2.9) | |
| 50–64 | 8914 | 314 (3.5) | |
| 65+ | 3000 | 248 (8.3) | |
| Year of Diagnosis | 0.166 | ||
| 2009 | 3324 | 162 (4.9) | |
| 2010 | 3186 | 134 (4.2) | |
| 2011 | 3256 | 136 (4.2) | |
| 2012 | 2546 | 98 (3.8) | |
| 2013 | 2432 | 105 (4.3) | |
| 2014 | 1712 | 57 (3.3) | |
| Any Trastuzumab Use After Diagnosis | <0.001 | ||
| No | 12131 | 322 (2.7) | |
| Yes | 4325 | 360 (8.3) | |
| Anthracyclines | 0.048 | ||
| No | 10870 | 433 (4.0) | |
| Yes | 5586 | 259 (4.6) | |
| Taxanes | <0.001 | ||
| No | 1621 | 96 (5.9) | |
| Yes | 14835 | 596 (4.0) | |
| Radiation | 0.968 | ||
| No | 5481 | 230 (4.2) | |
| Yes | 10975 | 462 (4.2) | |
| Deyo Comorbidity Score | <0.001 | ||
| 0 | 12680 | 436 (3.4) | |
| 1 | 3023 | 168 (5.6) | |
| 2+ | 753 | 88 (11.7) | |
| Hypertension | <0.001 | ||
| No | 10522 | 350 (3.3) | |
| Yes | 5934 | 342 (5.8) | |
| Diabetes | <0.001 | ||
| No | 14475 | 546 (3.8) | |
| Yes | 1981 | 146 (7.4) | |
| Coronary Artery Disease | <0.001 | ||
| No | 15816 | 615 (3.9) | |
| Yes | 640 | 77 (12.0) | |
| Valve Disease | <0.001 | ||
| No | 15824 | 628 (4.0) | |
| Yes | 632 | 64 (10.1) | |
| Insurance | 0.001 | ||
| PPO | 9608 | 361 (3.8) | |
| HMO | 2103 | 92 (4.4) | |
| Other | 4745 | 239 (5.0) | |
| Region | 0.003 | ||
| North Central | 3963 | 193 (4.9) | |
| Northeast | 2779 | 140 (5.0) | |
| South | 6507 | 234 (3.6) | |
| Unknown | 289 | 10 (3.5) | |
| West | 2918 | 115 (3.9) | |
*
P<0.05.