Table 2.

Relative Risk (RR) of Clinical Diagnosis of Incident AD dementia for Every 10 mm Hg Increase in Systolic BP and 5 mm Hg Increase in Diastolic BP Above and Below the BP Threshold

	RR (95% CI) No BP Meds	RR (95% CI) BP Meds	RR (95% CI) No ε4 Allele	RR (95% CI) Any ε4 Allele
N/AD	912/191	1225/246	1330/245	608/160
		Systolic BP
Linear Risk	0.95 (0.90, 1.00)	1.07 (1.02, 1.12)	1.02 (0.97, 1.06)	1.05 (0.98, 1.13)
SBP Threshold	150 (148, 153)	120 (110, 130)	143 (140, 146)	141 (138, 144)
10 mm Hg below	0.78 (0.72, 0.85)	0.80 (0.58, 1.09)	0.88 (0.80, 0.96)	0.70 (0.62, 0.80)
10 mm Hg above	1.30 (1.17, 1.44)	1.09 (1.04, 1.15)	1.13 (1.05, 1.21)	1.43 (1.29, 1.59)
		Diastolic BP
Linear Risk	0.92 (0.87, 0.97)	1.07 (1.02, 1.12)	1.02 (0.97, 1.07)	1.03 (0.97, 1.09)
DBP Threshold	84 (80, 88)	76 (74, 78)	–	76 (74, 78)
5 mm Hg below	0.90 (0.84, 0.96)	0.92 (0.83, 1.01)	–	0.74 (0.66, 0.83)
5 mm Hg above	1.03 (0.84, 1.26)	1.18 (1.10, 1.27)	–	1.32 (1.20, 1.44)
	No ε4 Allele		Any ε4 Allele
	No BP Meds	BP Meds	No BP Meds	BP Meds
N/AD	585/105	745/140	245/70	363/90
		Systolic BP
Linear Risk	0.89 (0.82, 0.97)	1.09 (1.03, 1.16)a	1.13 (1.02, 1.25)	1.00 (0.92, 1.10)
SBP Threshold	153 (150, 156)	-	139 (138, 140)	141 (138, 144)
10 mm Hg below	0.77 (0.69, 0.86)	-	0.56 (0.46, 0.68)	0.81 (0.67, 0.97)
10 mm Hg above	1.29 (1.08, 1.54)	-	2.00 (1.70, 2.31)	1.17 (1.02, 1.35)
		Diastolic BP
Linear Risk	0.92 (0.85, 0.99)a	1.09 (1.02, 1.16)a	1.00 (0.81, 1.23)	1.10 (0.94, 1.28)
DBP Threshold	-	-	76 (75, 77)	76 (74, 78)
5 mm Hg below	-	-	0.60 (0.51, 0.72)	0.83 (0.71, 0.97)
5 mm Hg above	-	-	1.57 (1.33, 1.86)	1.20 (1.07, 1.34)

^aNo observable change in pattern of log hazard function suggests the use of linear risk estimates

NOTE: Estimates adjusted for age, education, race, sex, heart disease, and diabetes. The presence of APOE ε4 allele adjusted for medication use, and medication use adjusted for APOE ε4 allele estimates