Table 1.
Chemical structure of the compounds 8a–h, their lipophilicity indices RM (RP-TLC) and log k (RP-HPLC) as well as retention times tr (RP-HPLC) estimated in the mobile phases consisted of a various volume ratio (v/v) of a methanol (MeOH) organic modifier and water.
 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Comp. | 1 RM | Mobile phase MeOH/water (v/v) | |||||||
| 60:40 | 70:30 | 80:20 | 85:15 | ||||||
| tr (min) | log k | tr (min) | log k | tr (min) | log k | tr (min) | log k | ||
| 8a | −0.55 | 6.593 | 0.612 | 3.587 | 0.248 | 2.493 | −0.034 | 2.200 | −0.156 |
| 8b | −0.35 | 7.707 | 0.695 | 4.893 | 0.444 | 2.907 | 0.095 | 2.433 | −0.056 |
| 8c | −0.16 | 8.933 | 0.771 | 5.907 | 0.552 | 3.193 | 0.166 | 2.620 | 0.010 |
| 8d | 0.01 | 10.021 | 0.829 | 7.820 | 0.702 | 3.586 | 0.245 | 2.830 | 0.074 |
| 8e | −0.02 | 5.307 | 0.491 | 3.180 | 0.163 | 2.360 | −0.085 | 2.120 | −0.196 |
| 8f | 0.19 | 7.153 | 0.656 | 3.953 | 0.312 | 2.620 | 0.010 | 2.275 | −0.121 |
| 8g | 0.39 | 8.280 | 0.732 | 5.320 | 0.492 | 3.033 | 0.128 | 2.533 | −0.020 |
| 8h | 0.63 | 11.035 | 0.881 | 7.287 | 0.665 | 3.543 | 0.240 | 2.814 | 0.069 |
1 RM, Lipophilicity index (RP-TLC). Silica gel plates (stationary phases) were impregnated by 1% silicone oil in heptane.