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. 2017 Nov 28;22(12):2081. doi: 10.3390/molecules22122081

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Inhibition of bFGF-mediated angiogenesis in the CAM model by 4 μg/20 μL/CAM of ajoene (8), allicin (1), difluoroalliicin 12, and S-2-fluoro-2-propenyl-l-cysteine (13); * p < 0.01 difluoroallicin (12) versus allicin (1) and ** p < 0.001 for all versus control FGF. Data showed that all organosulfur compounds tested demonstrated significant anti-angiogenesis activity, with greater efficacy for difluoroallicin 12 versus allicin (1). Data represent Mean (% inhibition of angiogenesis) ± SEM, n = 6–8 CAM/group.