Figure 8.

Superimposition of complexes of hBChE with aromatic compounds. In the A-site, choline-binding pocket residues are in yellow and acyl-binding pocket residues in magenta. P-site residues are in green. The gorge is depicted by its molecular surface (semi-transparent gray and magenta for the acyl-binding pocket). The ligands are represented in lines with the aromatic system involved in acyl-binding pocket interaction in sticks: propidium in cyan (pdb 6esj); ethropropazine in yellow (pdb 6eqp); huprine 19 in blue (pdb 6eqq); carbazole derivative in red (pdb 5k5e); dihydroindenylpiperidine naphthamide in green (pdb 4tpk); and benzylpiperidine naphthalene sulfoxamide in orange (pdb 5dyw).