Table 9.

Number of positive cells in Ames test of PLGA + IGF1.

Dose	TA 98		TA 100		TA 1535		TA 1537		E. coli wp2
cm2/mL	−S9	+S9	−S9	+S9	−S9	+S9	−S9	+S9	−S9	+S9
Spontaneous reversion	0.56 ± 0.53	1.67 ± 2.08	0.33 ± 0.58	0.67 ± 0.58	0.33 ± 0.58	2.00 ± 1.73	1.67 ± 1.53	4.33 ± 2.31	6.67 ± 1.53	5.00 ± 2.65
0.09375	0.33 ± 0.58	0.67 ± 1.15	0.33 ± 0.58	2.33 ± 0.58	1.67 ± 1.15	1.70 ± 1.53	0.00 ± 0.00	3.00 ± 1.00	10.00 ± 4.58	5.00 ± 1.00
0.1875	1.67 ± 1.15	1.33 ± 0.58	0.00 ± 0.00	1.67 ± 1.53	0.67 ± 1.15	1.67 ± 0.58	1.33 ± 1.53	2.00 ± 1.00	8.33 ± 5.13	3.67 ± 5.51
0.375	0.33 ± 0.58	2.67 ± 2.31	0.33 ± 0.58	1.33 ± 0.58	0.00 ± 0.00	1.33 ± 0.58	1.00 ± 1.00	3.67 ± 0.58	8.33 ± 2.52	5.00 ± 0.00
0.75	0.67 ± 1.15	5.00 ± 1.00	0.00 ± 0.00	2.00 ± 1.00	1.00 ± 0.00	2.67 ± 0.58	0.67 ± 0.58	2.33 ± 1.53	8.00 ± 3.46	7.67 ± 8.02
1.5	0.00 ± 0.00	2.67 ± 3.06	1.00 ± 1.00	2.00 ± 1.00	0.67 ± 0.58	1.00 ± 1.00	0.67 ± 0.58	3.00 ± 0.00	9.67 ± 4.62	8.00 ± 7.00
3	2.00 ± 1.00	3.00 ± 0.00	1.67 ± 1.53	0.67 ± 0.58	0.33 ± 0.58	1.67 ± 1.15	0.67 ± 0.58	2.33 ± 0.58	6.67 ± 1.53	9.33 ± 3.51
Positive control	40.67 ± 2.08	47.67 ± 0.58	36.33 ± 1.53	46.33 ± 2.08	48.00 ± 0.00	27.67 ± 2.08	48.00 ± 0.00	32.67 ± 7.37	45.33 ± 1.15	43.00 ± 1.00