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(a) 1-(phenylsulfonyl)spiro[indoline-3,3′-pyrrolidin]-2-one (17) superimposed onto the classical pharmacophore; (b) 1′-(phenylsulfonyl)spiro[indoline-3,3′-pyrrolidin]-2-one (18) fitting to the pharmacophore pattern lacking a positive ionisable moiety.
