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. 2017 Dec 12;22(12):2199. doi: 10.3390/molecules22122199

Figure 3.

Figure 3

Major histocompatibility complex. (A) Schematic representation of the gene encoding the three MHC classes, with the most important proteins roughly located; (B) Major histocompatibility complex class (MHC) I ribbon and surface structure (based on PDB code 5MEP) displaying the α-chain, the β-microglobulin as well as the closed groove for peptide antigen recognition [166]; (C) MHC class II ribbon and surface structure (based on PDB code 1A6A [167] displaying the α- and β-chains and the open groove for peptide antigen (IMPIPS 10022, sequence and colour code given) recognition [168] coloured according to the same color code for pockets P1, P4, P6 and P9.