Table 1.

Synthetic peptides as vaccines.

Name	Disease	Agent	Model & Outcome	Ref.
	Diphtheria	Corynebacterium diphtheriae	Guinea pigs became protected	[45]
	Foot-and-mouth disease	Foot-and-mouth disease virus	Neutralising antibodies induced in rabbits and guinea pigs	[46]
	Foot-and-mouth disease	Foot-and-mouth disease virus	Cattle became protected	[47]
	Malaria	Plasmodium berghei	Mice became protected	[38]
	Gastroenteritis	Simian rotavirus	Neutralising antibodies induced in rabbits	[48]
	Acquired immune deficiency syndrome	Human immunodeficiency virus	Neutralising antibodies induced in rabbits	[49]
First multi-epitope synthetic antimalarial vaccine	Malaria	Plasmodium falciparum	Aotus monkeys became protected	[39]
SPf66	Malaria	Plasmodium falciparum	Humans became protected	[11]
SPf66	Malaria	Plasmodium falciparum	Safe and highly-immunogenic in humans	[50,51,52]
SPf66	Malaria	Plasmodium falciparum	Protective efficacy (30–40%) in semi-immune populations	[12,53,54,55]
	Haemorrhagic enteritis, Myocarditis	Canine parvovirus	Dogs became protected	[56]
	Malaria	Plasmodium vivax	Parasite development in the mosquito was blocked	[57]
	Anthrax	Bacillus anthracis	Rabbit became protected	[58]
Fusion peptide	Influenza	Influenza A virus	Mice became protected	[59].
	Swine fever	Classical swine fever virus	Neutralising antibodies induced in pigs	[60]
CIGB-228	Cervical intraepithelial neoplasia	Human papilloma virus	Lesion regression and HPV clearance	[61].
IMPIPS	Malaria	Plasmodium falciparum	Aotus monkeys became protected	[62,63]