Table 1.
Univariate and multivariate Cox regression analyses for OS in microarray dataset
| Factors | Univariate analysis HR (95% CI) | P-value | Multivariate analysis HR (95% CI) | P-value |
|---|---|---|---|---|
| Age (years) | ||||
| Increasing years | 1.017 (1.008–1.027) | <0.001 | 1.027 (1.017–1.037) | <0.001 |
| Gender | ||||
| Male | 1 (reference) | |||
| Female | 0.838 (0.662–1.061) | 0.143 | ||
| Primary site | ||||
| Right-sided colon | 1 (reference) | |||
| Left-sided colon | 0.925 (0.690–1.239) | 0.599 | ||
| TNM stage | ||||
| I | 1 (reference) | 1 (reference) | ||
| II | 1.890 (0.953–3.746) | 0.068 | 1.842 (0.929–3.652) | 0.080 |
| III | 2.483 (1.254–4.920) | 0.009 | 2.451 (1.236–4.859) | 0.010 |
| IV | 10.834 (5.435–21.596) | <0.001 | 12.324 (6.171–24.613) | <0.001 |
| MMR status | ||||
| MMR-proficient | 1 (reference) | |||
| MMR-deficient | 0.773 (0.474–1.260) | 0.302 | ||
| Purity | ||||
| Low purity | 1 (reference) | 1 (reference) | ||
| High purity | 0.720 (0.570–0.909) | 0.006 | 0.307 (0.125–0.755) | 0.010 |
| Chemotherapy | ||||
| No | 1 (reference) | |||
| Yes | 0.933 (0.693–1.256) | 0.647 |
Notes: Bold values present p values where p<0.05
Abbreviations: OS, overall survival; TNM, tumor node metastasis; MMR, DNA mismatch repair.