Table S2.
The effect of anti-inflammatory drugs during treatment on cytokine level and development for patients with PTSD
| Variables | IL-1β
|
IL-1RA
|
MCP-1
|
TNF-α
|
||||
|---|---|---|---|---|---|---|---|---|
| Main effect of anti-inflammatory drugs
|
Anti-inflammatory interaction with time
|
Anti-inflammatory as main effect
|
Anti-inflammatory interaction with time
|
Anti-inflammatory as main effect
|
Anti-inflammatory interaction with time
|
Anti-inflammatory as main effect
|
Anti-inflammatory interaction with time
|
|
| β (SE)a | β (SE) | β (SE) | β (SE) | β (SE) | β (SE) | β (SE) | β (SE) | |
| Fixed effects | ||||||||
| Intercept | 0.068 (0.025)b | 0.062 (0.028)b | 38.907 (5.407)c | 38.477 (5.373)c | 24.387 (3.634) | 24.459 (3.642)c | 1.638 (0.587)d | 1.551 (0.596)c |
| Slope (time) | 0.012 (0.006)d | 0.01 (0.008) | 0.168 (0.255) | 0.231 (0.313) | 0.275 (0.195) | 0.219 (0.216) | 0.202 (0.080)b | 0.151 (0.094) |
| Anti-inflammatory | 0.472 (0.175)d | 0.489 (0.180)d | 3.577 (11.305) | 4.938 (12.888) | 4.459 (7.000)c | 4.223 (6.980) | 5.270 (2.677)b | 5.550 (2.680)b |
| Slope × anti-inflammatory | 0.006 (0.010) | −0.200 (0.536) | 0.181 (0.458) | 0.164 (0.173) | ||||
| Random effects | ||||||||
| Intercept | 0.129 (0.051)d | 0.129 (0.050)d | 922.953 (422.806) | 922.826 (417.926)d | 325.464 (63.951)c | 325.452 (63.838)c | 28.807 (11.361)d | 28.902 (11.265)d |
| Slope (time) | <0.001 (<0.001) | <0.001 (0.001) | 0.406 (1.933) | 0.411 (1.922) | 0.543 (0.353) | 0.536 (0.340) | 0.171 (0.196) | 0.176 (0.203) |
| Intercept × slope | 0.003 (0.002) | <0.001 (<0.001) | −4.401 (13.741) | −4.389 (13.195) | 2.921 (4.335) | 2.930 (4.201) | 0.673 (0.652) | 0.639 (0.585) |
| Fit indexe | ||||||||
| −2 LL | −23 | −23 | −503 | −503 | −468 | −468 | −334 | −334 |
| BIC | 90 | 94 | 1,049 | 1,053 | 969 | 973 | 711 | 715 |
Notes:
a
Regression coefficient.
b
P<0.05.
c
P<0.001.
d
P<0.01.
e
−2 LL.
Abbreviations: −2 LL, −2 log likelihood; BIC, Bayes information criterion; PTSD, posttraumatic stress disorder; SE, robust standard error.