Table 4.

MIC values of the compounds 1–8 and ebselen against Gram-negative ESKAPE strains.

	Bacterial Strain	MIC (µg/mL)
		1	2	3	4	5	6	7	8	Ebselen
K. pneumoniae	1	1.24 *	14	1.4–2.8	2.88–5.76	46	46	2.88	5.76	≥143
	2	0.62–1.24	6.88–14	1.4	2.88	35	17	2.88	5.76	108
	3	0.62	6.88	1.4	2.88	17	17	1.44–2.88	2.88	72
Acinetobacter spp.	4	0.31–0.62	0.86	0.35–0.7	0.36–0.72	2.88	1.44	0.36–0.72	1.44	18
	5	0.62	1.72–3.44	1.4	0.72	2.88–5.76	2.88	0.72	1.44–2.88	27
	6	0.31	0.86	0.35	0.36	2.88	0.72–1.44	0.36	1.44	18
P. aeruginosa	7	2.48	110	5.60–11	5.76–12	69	138	17	23	72
	8	0.31	1.72	0.7	1.44	12	12	0.72	1.44–2.88	18
	9	0.62–1.24	21	1.4–2.8	5.76	12	69	5.76	5.76–12	108
	10	0.62	6.88–14	1.4	2.88	17	23	2.88	5.76	27
E. coli	11	1.24–2.48	6.88–14	1.4	2.88	17	12	2.88	5.76	108
	12	1.24–2.48	6.88	1.4	2.88	17	12	1.44–2.88	5.76	72
	13	2.48	6.88–14	1.44–2.8	2.88	23	12	2.88	5.76	72
	14	1.24–2.48	14	2.8	5.76	23	17	2.88	5.76–12	54

* Particularly potent antibacterial activities (MIC < 5 μg/mL) are underlined. In case of MIC ≥ 10 µg/mL, the MIC values are expressed rounded to integers (see Supplementary for details). Bacterial strains—K. pneumoniae: (1) NRZ-00103, (2) KP 21513017, (3) KP 1963584; Acinetobacter spp.: (4) AC 2151300, (5) AB 1995594, (6) AB 4184/2/5; P. aeruginosa: (7) ATCC 27853, (8) PA T18, (9) PA54, (10) PA58; E. coli: (11) NCTC 13351, (12) EC 2151612, (13) EC 1995591, (14) EC 1227107.