Table 2.
Pharmacokinetic parameters for honokiol in rats after oral administration of free honokiol and honokiol nanoparticles
| Pharmacokinetic parameters | Free honokiol | Honokiol nanoparticles |
|---|---|---|
| Cmax (ng/mL) | 302.35 | 2,302.69 |
| Tmax (h) | 2 | 0.33 |
| t½ (h) | 1.42 | 3.03 |
| MRT(0–t) (h) | 5.90 | 5.14 |
| MRT(0–∞) (h) | 6.59 | 5.22 |
| AUC(0–t) (ng/mL·h) | 1,564.03 | 10,197.20 |
| AUC(0–∞) (ng/mL·h) | 1,623.67 | 10,245.12 |
Abbreviations: AUC, area under the curve; Cmax, maximum serum concentration; MRT, mean residence time; t½, half-life of drug; Tmax, time taken to achieve Cmax.