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. 2017 Nov 24;22(12):2027. doi: 10.3390/molecules22122027

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Evaluation of intrinsic disorder propensities of 33 proteins associated with the proteins caused by the nucleotide expansions. Intrinsic disorder predisposition was evaluated by PONDR^® VSL2 predictor, which is one of the more accurate stand-alone tools for prediction of the intrinsic disorder status of a target protein. This tool is known to be statistically better for proteins containing both ordered and disordered regions [208,209]. (A) Homeobox protein HOXD13 (UniProt ID: P35453); (B) Homeobox protein HOXA13 (UniProt ID: P31271); (C) runt-related transcription factor 2, RUNX2 (UniProt ID: Q13950); (D) Zinc finger protein ZIC2 (UniProt ID: O95409); (E) Paired mesoderm homeobox protein 2B (UniProt ID: Q99453); (F) Transcription factor SOX3 (UniProt ID: P41225); (G) Homeobox protein ARX (UniProt ID: Q96QS3); (H) Human FOXL2 (UniProt ID: P58012); (I) PABP2/PABPN1 (UniProt ID: Q86U42); (J) Small conductance calcium-activated potassium channel protein 3 (SK3, UniProt ID: Q9UGI6); (K) Human junctophilin-3 (JP-3, UniProt ID: Q8WXH2); (L) Human huntingtin (UniProt ID: P42858); (M) Atrophin-1 (UniProt ID: P54259); (N) Human androgen receptor (AR, UniProt ID: P10275); (O) Ataxin-1 (UniProt ID: P54253); (P) Ataxin-2 (UniProt ID: Q99700); (Q) Human ataxin-3 (UniProt ID: P54252); (R) Voltage-dependent P/Q-type calcium channel subunit α1A (CACNA1A, UniProt ID: O00555); (S) Ataxin-7 (UniProt ID: O15265); (T) TATA-box-binding protein (TBP, UniProt ID: P20226); (U) Synaptic functional regulator FMR1 (UniProt ID: Q06787); (V) Disco-interacting protein 2 homolog B (UniProt ID: Q9P265); (W) AF4/FMR2 family member 2 (UniProt ID: P51816); (X) C9orf72 (UniProt ID: Q96LT7); (Y) Frataxin (UniProt ID: Q16595); (Z) Cellular nucleic acid-binding protein (CNBP, UniProt ID: P62633); (a) Ataxin-10 (UniProt ID: Q9UBB4); (b) Nucleolar protein 56 (UniProt ID: O00567); (c) Transcription factor 4 (UniProt ID: P15884); (d) Myotonin-protein kinase (UniProt ID: Q09013); (e) Ataxin-8 (UniProt ID: Q156A1); (f) ATXN8OS protein (UniProt ID: P0DMR3); (g) Cystatin-B (UniProt ID: P04080); (h) Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B β isoform (PPP2R2B, UniProt ID: Q00005). In this analysis, scores above 0.5 correspond to intrinsic disorder.