Table 3.

In vitro antitumor activity of compounds 1–10 in a panel of 8 tumor cell lines.

Compounds	HL-60	Hela	HCT15	A459	HepG2	PC-3	CNE-2	BGC-823
1	>100.0	>100.0	87.6 ± 1.2	77.7 ± 1.6	37.6 ± 1.4	>100.0	>100.0	>100.0
2	>100.0	>100.0	>100.0	>100.0	>100.0	>100.0	>100.0	>100.0
3	17.1 ± 0.7	62.2 ± 0.5	9.6 ± 0.8	14.8 ± 0.9	11.4 ± 1.6	26.2 ± 1.3	21.5 ± 0.6	13.4 ± 1.1
4	74.8 ± 1.3	89.3 ± 1.8	37.3 ± 1.5	33.6 ± 1.1	49.5 ± 1.4	64.0 ± 0.9	55.2 ± 1.1	44.1 ± 1.7
5	>100.0	>100.0	>100.0	>100.0	>100.0	>100.0	>100.0	>100.0
6	>100.0	>100.0	>100.0	>100.0	>100.0	>100.0	>100.0	>100.0
7	>100.0	>100.0	71.3 ± 1.2	50.4 ± 1.1	>100.0	34.2 ± 1.3	>100.0	>100.0
8	>100.0	>100.0	89.8 ± 1.2	91.3 ± 0.7	>100.0	>100.0	>100.0	>100.0
9	>100.0	>100.0	96.1 ± 1.6	78.3 ± 0.8	97.9 ± 1.4	>100.0	>100.0	>100.0
10	>100.0	>100.0	>100.0	>100.0	>100.0	>100.0	>100.0	>100.0
5-Fluorouracil	7.5 ± 0.6	10.4 ± 0.4	4.7 ± 0.4	14.7 ± 1.1	22.8 ± 1.4	13.2 ± 0.7	11.6 ± 0.8	17.8 ± 0.7

Key: All results are expressed as IC₅₀ values in μM. Compounds with IC₅₀ > 100 μM were inactive for the tumor cell lines.