Table 4.
Diagnostic performance of AFP and miRNAs for discriminating HCC patients from Control group and CHC patients.
| Sensitivity % | Specificity % | Cut-off | Accuracy | p-value | |
|---|---|---|---|---|---|
| HCC vs. control | |||||
| AFP | 57.5 | 95 | >10 (ng/ml) | 0.70 | 0.01 |
| MiR-122 | 87.5 | 95 | <0.67 (RQ) | 0.96 | <0.001 |
| MiR-224 | 92.5 | 90 | >1.2 (RQ) | 0.94 | <0.001 |
| HCC vs. CHC | |||||
| AFP | 58% | 100% | >85.9 (ng/ml) | 0.62 | 0.06 |
| MiR-122 | 87.5% | 97.5% | <0.21 (RQ) | 0.98 | <0.001 |
| MiR-224 | 87.5% | 97% | >3.9 (RQ) | 0.93 | <0.001 |
| AFP + miR-122 | 97.5% | 100% | – | 1 | <0.001 |
| AFP + miR-224 | 90% | 100% | – | 0.93 | <0.001 |