Figure 1.

(A) A representative non-affected normocellular glomerulus. The glomerular capillary lumina are largely patent without significant endocapillary, mesangial or extracapillary proliferation (Periodic acid-Schiff, magnification x400). (B) An affected glomerulus displays segmental fibrinoid necrosis (arrow) (H&E, magnification x400). (C) A glomerulus containing cellular crescent (arrow) (Periodic acid-Schiff, magnification x400). (D) The glomeruli display largely mesangial staining for IgG (fluorescence micrograph, magnification x400). (E) Mesangial and subendothelial electron dense immune-type deposits are identified. A focal mesangial electron dense deposit is seen (red arrow). (Electron micrograph, magnification x6000).