Table 3.

The half maximal effective concentration (EC₅₀) of cell lines expressing nAChR in vitro for different alkaloids and their enantiomers [110,119].

	EC50 of the Cell Line Expressing nAChR
Alkaloid	TE-671	SH-SY5Y
(−)-coniine	115 μM	9.6 μM
(±)-coniine	208 μM	51.4 μM
(+)-coniine	900 μM	10.2 μM
γ-coniceine	1.3 μM	-
(−)-N-methylconiine	105 μM	-
(±)-N-methylconiine	405 μM	-
(+)-N-methylconiine	3000 μM	-