Table 1.
Effects of Shenxiong glucose injection (SGI) on pharmacokinetic parameter of caffeine (1.0 mg/kg).
| Parameters | BCG | Treatment Groups | |
|---|---|---|---|
| 7D-G | 14D-G | ||
| AUC(0–t)(mg/L·h) | 2.62 ± 0.68 | 2.61 ± 1.09 | 2.38 ± 0.41 |
| AUC(0–∞)(mg/L·h) | 3.42 ± 0.79 | 3.24 ± 0.96 | 2.92 ± 0.59 |
| MRT(0–t)(h) | 1.37 ± 0.15 | 1.46 ± 0.18 | 1.35 ± 0.17 |
| MRT(0–∞)(h) | 3.70 ± 2.96 | 3.37 ± 2.01 | 2.77 ± 1.17 |
| t1/2(h) | 3.33 ± 2.56 | 2.89 ± 1.84 | 2.64 ± 1.04 |
| CL(L/h/kg) | 0.77 ± 0.18 | 0.83 ± 0.23 | 0.89 ± 0.18 |
| Vd(L/kg) | 3.40 ± 1.97 | 3.51 ± 2.24 | 3.25 ± 1.00 |
BCG, blank control group (0.9% sodium chloride solution for 10 days); 7D-G, short-period group (5 mL/kg of SGI concentrated solution, iv, once daily for consecutive 7 days); 14D-G, long-period group (5 mL/kg of SGI concentrated solution, iv, once daily for consecutive 14 days). Values are represented as mean ± SD (n = 6).