Table 6.

Effects of SGI on pharmacokinetic parameter of midazolam (4.0 mg/kg).

Parameters	BCG	Treatment Groups
		7D-G	14D-G
AUC(0–t)(mg/L·h)	6.16 ± 0.38	6.17 ± 0.92	6.62 ± 1.59
AUC(0–∞)(mg/L·h)	6.25 ± 0.40	6.65 ± 1.46	6.73 ± 1.56
MRT(0–t)(h)	2.39 ± 0.16	2.36 ± 0.14	2.25 ± 0.34
MRT(0–∞)(h)	2.53 ± 0.17	3.15 ± 0.92	2.42 ± 0.43
t1/2(h)	1.76 ± 0.12	2.55 ± 1.23	1.83 ± 0.38
CL(L/h/kg)	0.64 ± 0.04	0.62 ± 0.13	0.62 ± 0.15
Vd(L/kg)	1.63 ± 0.16	2.12 ± 0.58	1.67 ± 0.55

BCG, blank control group (0.9% sodium chloride solution for 10 days); 7D-G, short-period group (5 mL/kg of SGI concentrated solution, iv, once daily for consecutive 7 days); 14D-G, long-period group (5 mL/kg of SGI concentrated solution, iv, once daily for consecutive 14 days). Values are represented as mean ± SD (n = 6).