Table 8.

Single-ion recording (SIR) transitions and cone voltages for the detection of CYP probe substrates and internal standard.

Probe Drugs	Polarity	Molecular Mass	Parent (m/z)	Cone (V)
Caffeine	ESI+	194	195	35
Tolbutamide	ESI–	270	269	40
Omeprazole	ESI+	345	346	35
Metoprolol	ESI+	267	268	20
Chlorzoxazone	ESI–	169	168	35
Midazolam	ESI+	325	326	30
Puerarin (IS 1)	ESI+	416	417	40