Table 1.
Experimental parameters of Box–Behnken design and extraction yields of three cannabinoids.
| Run | Factor (Coded) | Measured Response | ||||
|---|---|---|---|---|---|---|
| X1 (W) | X2 (°C) | X3 (min) | THC (μg/g) | CBD (μg/g) | CBN (μg/g) | |
| 1 | 300 (−1) | 80 (−1) | 20 (0) | 2.18 | 1.79 | 0.79 |
| 2 | 1300 (+1) | 80 (−1) | 20 (0) | 2.13 | 1.78 | 0.78 |
| 3 | 300 (−1) | 160 (+1) | 20 (0) | 1.77 | 2.14 | 0.82 |
| 4 | 1300 (+1) | 160 (+1) | 20 (0) | 1.44 | 1.65 | 0.85 |
| 5 | 300 (−1) | 120 (0) | 10 (−1) | 2.13 | 2.19 | 0.89 |
| 6 | 1300 (+1) | 120 (0) | 10 (−1) | 2.38 | 2.57 | 0.98 |
| 7 | 300 (−1) | 120 (0) | 30 (+1) | 2.19 | 2.55 | 1.05 |
| 8 | 1300 (+1) | 120 (0) | 30 (+1) | 2.23 | 2.28 | 0.96 |
| 9 | 800 (0) | 80 (−1) | 10 (−1) | 2.05 | 2.16 | 0.98 |
| 10 | 800 (0) | 160 (+1) | 10 (−1) | 1.35 | 1.51 | 0.65 |
| 11 | 800 (0) | 80 (−1) | 30 (+1) | 2.65 | 2.22 | 0.90 |
| 12 | 800 (0) | 160 (+1) | 30 (+1) | 1.51 | 1.83 | 0.55 |
| 13 | 800 (0) | 120 (0) | 20 (0) | 2.40 | 2.17 | 0.90 |
| 14 | 800 (0) | 120 (0) | 20 (0) | 2.21 | 2.57 | 1.14 |
| 15 | 800 (0) | 120 (0) | 20 (0) | 1.94 | 2.40 | 0.89 |
| 16 | 800 (0) | 120 (0) | 20 (0) | 2.21 | 2.33 | 0.95 |
| 17 | 800 (0) | 120 (0) | 20 (0) | 2.15 | 2.61 | 0.96 |
X1: microwave power, X2: temperature, X3: extraction time. THC; Δ9-tetrahydrocannabinol, CBD; cannabidiol, CBN; cannabinol.