. 2017 Nov 4;22(11):1733. doi: 10.3390/molecules22111733

Table 1.

Minimum inhibitory concentration (MIC) and FIC indices of essential oil-meropenem pairs against K. pneumoniae BAA-1705.

Combinations of Essential Oils and Meropenem	K. pneumoniae BAA-1705				Type of Interaction
Combinations of Essential Oils and Meropenem	MIC_O	MIC_C	FICI	FICIc	Type of Interaction
Cinnamon Bark-Meropenem Cinnamon Bark (%)	0.16	0.08	0.50	1.00	Additive
Meropenem (μg/mL)	32	16	0.50
Marjoram-Meropenem Marjoram (%)	1.25	0.63	0.50	0.56	Additive
Meropenem (μg/mL)	32	2	0.06
Peppermint-Meropenem Peppermint (%)	1.25	0.63	0.50	0.56	Additive
Meropenem (μg/mL)	32	2	0.06
Tea Tree-Meropenem Tea Tree (%)	1.25	0.63	0.50	0.52	Additive
Meropenem (μg/mL)	32	0.5	0.02

MIC_O, MIC of one sample alone; MIC_C, MIC of one sample in the most effective combination. FICIc, total FIC of the combination of both sample, FICIc ≤ 0.5, synergistic; FICIc > 0.5–4.0, additive; FICIc > 4.0, antagonistic [8,17].