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. 2017 Oct 27;22(11):1840. doi: 10.3390/molecules22111840

Figure 1.

Figure 1

Chemical structure of (A) PNA monomer; (B) ethylene glycol-based aminoethoxyethoxy acetate linker (AEEA); (C) azobenzene amino acid linker (C0-AZO); and (D) spacer conjugated azobenzene amino acid linker (C3-, C4-, C5- and C6-AZO (n = 1, 2, 3 and 4)); (E) Schematic image of triplex formation between TC-PNA and ssDNA. The C-terminal strand (PNA (WC)) of TC-PNA was designed to form Watson-Crick base pairs and the N-terminal strand (PNA (H)) of TC-PNA was designed to form Hoogsteen base pairs with its target ssDNA; and (F) one possible image of a TC-PNA/TC-PNA/ssDNA trimer.