Table 4.
Body weight of Plasmodium berghei-infected mice before and after administration of solvent fractions.
| Fraction | Dose (mg/kg/Day) | Wt (g) D0 ± SD | Wt (g) D4 ± SD | % Change |
|---|---|---|---|---|
| Hexane | 100 | 25.6 ± 0.2 | 26.0 ± 0.4 | 1.5 |
| Hexane | 200 | 25.5 ± 1.3 | 26.2 ± 0.5 | 2.4 |
| Hexane | 400 | 25.4 ± 0.3 | 26.3 ± 1.1 | 3.7 |
| Vehicle | 0.5 mL | 26.2 ± 0.2 | 24.5 ± 0.5 | −6.3 2 |
| CQ | 25 | 25.4 ± 0.5 | 26.5 ± 0.3 | 4.2 2 |
| Dichloromethane | 100 | 28.3 ± 3.0 | 29.0 ± 1.5 | 2.6 |
| Dichloromethane | 200 | 26.8 ± 3.4 | 27.7 ± 3.7 | 3.5 |
| Dichloromethane | 400 | 25.9 ± 3.3 | 27.1 ± 3.7 | 4.7 |
| Vehicle | 0.5 mL | 27.9 ± 3.00 | 26.3 ± 4.4 | −5.8 |
| CQ | 25 | 25.4 ± 0.5 | 26.5 ± 0.3 | 4.2 2 |
| Ethyl acetate | 100 | 26.2 ± 0.7 | 26.4 ± 1.6 | 0.6 |
| Ethyl acetate | 200 | 25.0 ± 2.5 | 26.1 ± 2.5 | 4.3 |
| Ethyl acetate | 400 | 25.6 ± 2.6 | 26.5 ± 3.1 | 3.4 |
| Vehicle | 0.5 mL | 26.8 ± 3.5 | 26.1 ± 5.9 | −2.5 |
| CQ | 25 | 28.8 ± 5.1 | 29.8 ± 4.5 | 3.6 |
| Aqueous | 100 | 25.8 ± 2.1 | 26.7 ± 1.8 | 3.3 |
| Aqueous | 200 | 25.1 ± 2.5 | 25.7 ± 2.4 | 2.8 |
| Aqueous | 400 | 27.2 ± 2.3 | 27.9 ± 2.5 | 2.5 |
| Vehicle | 0.5 mL | 26.8 ± 3.5 | 26.1 ± 5.9 | −2.5 |
| CQ | 25 | 28.8 ± 5.1 | 29.8 ± 4.5 | 3.6 |
Values are presented as M ± SEM; n = 5, Wt D0 = weight day zero; Wt D4 = weight day four; 2 = p < 0.001, comparison was made between weight before and after treatment.