Table 6.
Body weight of Plasmodium berghei-infected mice before and after administration of EH-1 and EH-5.
| Test | Dose | Wt(g) D0 ± SD | Wt (g) D4 ± SD | % Change |
|---|---|---|---|---|
| EH-1 | 50 mg/kg | 26.3 ± 2.4 | 26.6 ± 1.6 | 1.1 |
| EH-1 | 100 mg/kg | 22.4 ± 1.9 | 22.6 ± 1.6 | 0.8 |
| Vehicle | 0.5 mL | 23.5 ± 1.6 | 23.1 ± 1.8 | −1.5 |
| CQ | 25 mg/kg | 27.6 ± 2.5 | 28.8 ± 2.7 | 4.4 1 |
| EH-5 | 50 mg/kg | 22.0 ± 1.0 | 22.2 ± 2.1 | 0.9 |
| EH-5 | 100 mg/kg | 24.2 ± 2.6 | 25.4 ± 3.0 | 4.9 |
| Vehicle | 0.5 mL | 24.0 ± 3.3 | 23.6 ± 2.9 | −1.7 |
| CQ | 25 mg/kg | 21.8 ± 1.6 | 24.1 ± 2.6 | 10.6 1 |
Values are presented as M ± SD; n = 5, Wt D0 = weight day zero; Wt D4 = weight day four; 1 = p < 0.05, comparison was made between weight before and after treatment.