Table 1.
IC50 values for the inhibition of viral influenza A (H1N1) neuraminidase (H1N1-NA) and bacterial Vibrio cholerae neuraminidase (VCNA) by flavan-3-ols.
| Test Substance | IC50 (Viral) µg/mL µM | IC50 (Bacterial) µg/mL µM | ||
|---|---|---|---|---|
| Positive control | ||||
| oseltamivir carboxylate | 2.9 ± 0.2 (1) | 0.01 ± 0.001 | 41 ± 1 | 144 ± 1 |
| zanamivir | 3.7 ± 0.4 (1) | 0.01 ± 0.001 | 17 ± 1 | 52 ± 2 |
| Flavan-3-ols | ||||
| catechin | 312 ± 21 | 1076 ± 75 | 595 ± 25 | 2050 ± 87 |
| gallocatechin | 547 ± 23 | 1787 ± 74 | 603 ± 61 | 1969 ± 199 |
| catechin-3-O-gallate | 862 ± 2 | 1949 ± 4 | 24 ± 2 | 55 ± 4 |
| gallocatechin-3-O-gallate | 181 ± 3 | 396 ± 7 | 11 ± 1 | 25 ± 2 |
| epicatechin | 305 ± 19 | 1053 ± 64 | 670 ± 29 | 2186 ± 99 |
| epigallocatechin | 532 ± 41 | 1739 ± 135 | 598 ± 57 | 1955 ± 185 |
| epicatechin-3-O-gallate | 845 ± 24 | 1910 ± 55 | 93 ± 8 | 211 ± 19 |
| epigallocatechin-3-O-gallate | 717 ± 63 | 1565 ± 137 | 29 ± 1 | 64 ± 3 |
IC50 values are expressed as mean ± standard deviation (SD) (n = 3–6 independent experiments); (1) data are in ng/mL.