Table 2.
IC50 values for the inhibition of viral H1N1-NA and bacterial VCNA by ellagitannins.
| Test Substance | IC50 (Viral) µg/mL µM | IC50 (Bacterial) µg/mL µM | ||
|---|---|---|---|---|
| Positive control | ||||
| oseltamivir acid | 2.9 ± 0.2 (1) | 0.01 ± 0.001 | 41 ± 1 | 144 ± 1 |
| zanamivir | 3.7 ± 0.4 (1) | 0.01 ± 0.001 | 17 ± 1 | 52 ± 2 |
| Ellagitannins | ||||
| dehydroellagitannin members | ||||
| geraniin | - | - | 128 ± 2 | 135 ± 2 |
| granatin A | - | - | 124 ± 2 | 158 ± 4 |
| carpinusin | - | - | 131 ± 5 | 138 ± 5 |
| terchebin | 97 ± 2 | 101 ± 3 | 29 ± 2 | 31 ± 2 |
| C-glycosidic members | ||||
| casuariin | - | - | 185 ± 4 | 236 ± 5 |
| vescalagin | - | - | 125 ± 11 | 73 ± 11 |
| paeonianin C | 587 ± 24 | 344 ± 14 | 25 ± 2 | 15 ± 1 |
IC50 values are expressed as mean ± SD (n = 3–6 independent experiments); (1) data are in ng/mL.