Table 1.

Rh123 transport in the presence and absence of verapamil in MDCK-pHaMDR cell monolayer.

Analytes	Papp AP→BL (×10−7 cm/s)	Papp BL→AP (×10−7 cm/s)	Efflux Ratio
Rh123	8.43 ± 1.95	57.99 ± 2.59	6.88
Rh123 + verapamil	12.70 ± 2.13 *	17.07 ± 0.99 **	1.34

P_{app AP→BL}: transport from apical (AP) to basolateral (BL) side; P_{app BL→AP}: transport from BL to AP side. Efflux Ratio: P_{app BL→AP}/P_{app AP→BL}. Rh123 at 10 μM was transport with 100 μM of verapamil with an incubation time of up to 90 min. Data are the mean ± SD (n = 6). * p < 0.05, ** p < 0.001 vs. Rh123 group).