Table 1.
Examples of some of the most popular currently available docking software. For a comprehensive list see [15].
| Software | Searching Algorithm | Native Scoring Function 1 | License |
|---|---|---|---|
| AutoDock [16] | Stochastic | Force-Field based | Free for Academia |
| DOCK [17] | Systematic | Force-Field based | Free for Academia |
| FlexX [18] | Systematic | Empirical | Paid |
| Glide [19] | Systematic | Empirical | Paid |
| GOLD [20] | Stochastic | Force-Field based | Paid |
| ICM [21] | Stochastic | Force-Field based | Paid |
| MOE [22] | Stochastic | Force-Field based | Paid |
1 Usually, the user can choose among several, often customizable, scoring functions. Here we report the type of scoring functions originally developed with the docking program.