Table 1.
Software | Searching Algorithm | Native Scoring Function 1 | License |
---|---|---|---|
AutoDock [16] | Stochastic | Force-Field based | Free for Academia |
DOCK [17] | Systematic | Force-Field based | Free for Academia |
FlexX [18] | Systematic | Empirical | Paid |
Glide [19] | Systematic | Empirical | Paid |
GOLD [20] | Stochastic | Force-Field based | Paid |
ICM [21] | Stochastic | Force-Field based | Paid |
MOE [22] | Stochastic | Force-Field based | Paid |
1 Usually, the user can choose among several, often customizable, scoring functions. Here we report the type of scoring functions originally developed with the docking program.