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. 2018 Aug 12;41(10):2178–2186. doi: 10.2337/dc18-0777

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© 2018 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

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The fecal meta-proteome distinguishes individuals with islet autoimmunity and new-onset (NO) patients from control subjects. A: sPLS-DA of all human and microbial proteins comparing NO, seropositive (SP), and combined healthy control and seronegative (CO/SN) groups. B: Component 1 contributing variables. Red text, human proteins; black text, microbial proteins; 158742018-stool1_revised_scaffold9355_1_gene110855 abbreviated as gene11085. C: Log-normalized intensity of significant proteins comparing NO, SP, and CO/SN subject groups by one-way ANOVA (adjusted P < 0.05). Data are mean ± SEM. D and E: sPLS-DA of human and microbial proteins, respectively, comparing NO, SP, and CO/SN subject groups. A PERMANOVA comparing the three groups is shown. *P < 0.05; **P < 0.01; ***P < 0.001.