Table 1.

Several aggregate-forming small molecules. Critical aggregation concentrations for these compounds are provided for the aqueous conditions listed. Error (standard deviation) is included when known.

Compound (Indication)	MW (g/mol)	CAC (μM)	Aqueous Conditions
Brazilin (natural product) [14]	286.3	57 ± 7	50 mM potassium phosphate, pH 7
Cinnarizine (anti-histamine) [7]	368.5	7 ± 3	50 mM potassium phosphate, pH 7
Clotrimazole (anti-fungal) [15]	344.8	15.0 ± 0.3	100 mM potassium phosphate, pH 10
Crizotinib (anti-neoplastic, non-small cell lung cancer) [16]	450.3	19.3	50 mM potassium phosphate, pH 7
Curcumin (natural product) [14]	368.4	17 ± 0.44	50 mM potassium phosphate, pH 7
Danazol (synthetic steroid) [17]	337.5	39	10 mM phosphate buffer, pH 6.8
Emodin (natural product) [14]	270.2	28 ± 2	50 mM potassium phosphate, pH 7
Evacetrapib (cholesterylester transfer protein inhibitor) [18]	638.7	0.8	50 mM sodium phosphate, pH 6.8
Felodipine (calcium channel blocker) [15]	384.3	26 ± 1	50 mM sodium phosphate, pH 6.8
Fulvestrant (anti-neoplastic, breast cancer) [16]	606.8	0.5	50 mM potassium phosphate, pH 7
Miconazole (anti-fungal) [7]	416.1	3 ± 2	50 mM potassium phosphate, pH 7
Nicardipine (calcium channel blocker) [7]	479.5	32 ± 3	50 mM potassium phosphate, pH 7
Pentyl-PABC doxazolidine (investigational anti-neoplastic) [19]	818.8	14	Phosphate buffered saline, pH 7.4
Ritonavir (anti-retroviral) [15]	720.9	26.1 ± 0.1	50 mM sodium phosphate, pH 6.8
Sorafenib (anti-neoplastic, renal cell carcinoma) [16]	464.8	3.5	50 mM potassium phosphate, pH 7
Tetraiodophenolphthalein (indicator) [7]	821.9	10 ± 2	50 mM potassium phosphate, pH 7
Trypan blue (dye) [20]	872.9	30	50 mM potassium phosphate, pH 7
Vemurafenib (anti-neoplastic, melanoma) [16]	489.9	1.2	50 mM potassium phosphate, pH 7