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. 2018 Sep 21;13(9):e0204100. doi: 10.1371/journal.pone.0204100

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© 2018 Muthiah et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 5 — (a) Strong correlation of expression patterns of KLF4, IRS2 and TSC2 across different conditions (DC8, DW8, DC16, DW16), but little correlation with expression of the negative control gene, MTAP1B, across the different conditions. (b) Since KLF4 is a known transcriptional regulator and KLF4 binding motifs are present in IRS2 and TSC2 gene promoters, we conjectured that KLF4 regulates the expression of the two genes. (c) Relative mRNA expression levels (shown as means +/- SEM) of IRS2 (left panel) and TSC2 (right panel) in adipose tissues of KLF4-deficient (KLF4^+/-, N = 4) and KLF4 wild type (KLF4^+/+, N = 4) adipose tissues with fold changes (FC) as indicated. * p = 0.06 and ** p <0.05. The relative expression levels of MTAP1B mRNA were not different between KLF4^+/- and KLF4^+/+ adipose tissues.