Fig 4. The evolution of the distribution of the number of chromosome copies for the various models.

Each curve represents a given number of copies. A—D: Basic model ($\mathcal{M}$) with N = 8 (except in D, which uses N = 16), over 2000 generations. E—L: Full model with chromosome scores ($\mathcal{A}$) with N = 8 and a founder cell with f = 2 chromosome copies, over 2000 generations. M—P: Modified model incorporating the effects of aneuploidy during early tumor growth (${\mathcal{A}}_X$) with N = 8 and a founder cell with 2 active copies of gene X, over 1000 generations.