Table 1.
Monoclonal antibodies in this study.
| mAb number | Immunoglobin type | Human or Humanized | Type of mAb target | AC-SINS Score | Species | Linear dose range (mg/kg) | Dose levels excluded (mg/kg) | Number of dose levels included |
|---|---|---|---|---|---|---|---|---|
| mAb1 | IgG2 | Human | membrane bound | — | Cyno | 2 | None | 1 |
| mAb2 | IgG2 | Humanized | soluble | — | Cyno | 10– 100 | None | 3 |
| mAb3 | IgG2 | Humanized | soluble | 3 | Cyno, Tg32 Mice | 1–10, 5 | None, None | 2, 1 |
| mAb4 | IgG2 | Human | membrane bound | — | Cyno | 1–10 | 0.01–0.3 | 2 |
| mAb5 | IgG2 | Human | membrane bound | — | Human, Cyno | 1–15, 5–50 | 0.5, None | 8, 2 |
| mAb6 | IgG2 | Human | membrane bound | — | Human | 0.1–15 | None | 6 |
| mAb7 | IgG2 | Human | membrane bound | — | Human, Cyno | 0.2–20, 30–100 | None, 3–5 | 8, 2 |
| mAb8 | IgG1 | Human | membrane bound | — | Cyno | 3–30 | 0.3 | 2 |
| mAb9 | IgG1 | Humanized | soluble | — | Human, Cyno | 1.5–5, 1–10 | 0.5, None | 2, 2 |
| mAb10 | IgG2 | Humanized | soluble | — | Human, Cyno | 1–24, 1–100 | 0.3, 0.1 | 6, 3 |
| mAb11 | IgG2 | Human | soluble | — | Cyno | 1– 5 | None | 2 |
| mAb12 | IgG1 | Human | soluble | — | Human, Cyno | 5–600, 2 | None | 6, 1 |
| mAb13 | IgG1 | Synthetic | soluble | — | Cyno | 2 | None | 1 |
| mAb14 | IgG2 | Humanized | soluble | — | Human, Cyno | 1–18, 3–100 | 0.3, 0.1–0.3 | 6, 3 |
| mAb15 | IgG2 | Humanized | soluble | — | Human | 1–6 | None | 3 |
| mAb16 | IgG2 | Humanized | soluble | — | Human, Cyno | 0.1–10, 0.8–16.5 | 0.01–0.03, None | 4, 3 |
| mAb17 | IgG2 | Humanized | soluble | — | Human, Cyno | 1–10, 10–200 | 0.1–0.3, None | 4, 3 |
| mAb18 | IgG1 | Human | membrane bound | 24 | Human, Cyno, Tg32 Mice | 30–120 mg, 2–10, 5 | None, None, None | 3, 2, 1 |
| mAb19 | IgG1 | Human | membrane bound | 17 | Human, Cyno, Tg32 Mice | 1–8, 0.5–5, 5 | 0.5, None, None | 4, 2, 1 |
| mAb20 | IgG2 | Human | membrane bound and soluble | 0 | Human, Cyno, Tg32 Mice | 0.3–10, 1–100, 5 | 0.03– 0.1, None, None | 3, 3, 1 |
| mAb21 | IgG1 | Human | membrane bound and soluble | 6 | Human, Cyno, Tg32 Mice | 10–800 mg, 10–100, 5 | 1– 3 mg, None, None | 4, 2, 1 |
| mAb22 | IgG2 | Human | soluble | 1 | Human, Cyno, Tg32 Mice | 22–700 mg, 0.5–5 | 7 mg, None, None | 6, 2 |
| mAb23 | IgG1 | Humanized | soluble | 0 | Human, Cyno, Tg32 Mice | 3, 1–100, 5 | None, None, None | 1, 2, 1 |
| mAb24 | IgG1 | Humanized | soluble | 1 | Human, Cyno, Tg32 Mice | 3, 1–100, 5 | None, None, None | 1, 2, 1 |
| mAb25 | IgG1 | Human | soluble | 10 | Human, Cyno, Tg32 Mice | 0.3– 11.25, 50, 5 | None, None, None | 5, 1, 1 |
| mAb26 | IgG1 | Human | membrane bound | 21 | Tg32 Mice | 5 | None | 1 |
| mAb27 | IgG1 | Human | soluble | 2 | Tg32 Mice | 5 | None | 1 |