Comparison of observed human PK parameters for individual mAbs with ‘typical’ human popPK parameter estimates.

	CL mL/h/kg	V1 mL/kg	Q mL/h/kg	V2 mL/kg	%RMSE
Human PopPK	0.15	46.31	0.27	31.47	—
Observed Human PK
mAb5	0.26	54.50	0.30	33.29	50.6
mAb6	0.12	52.58	0.32	31.76	23.1
mAb7	0.21	57.04	0.68	16.38	31.4
mAb9	0.12	46.58	0.37	40.47	24.7
mAb10	0.07	34.62	0.25	24.39	53.8
mAb12	0.17	40.49	0.25	32.75	18.2
mAb14	0.18	38.51	0.31	15.70	32.8
mAb15	0.17	39.11	0.43	44.99	19.7
mAb16	0.10	40.23	0.36	42.42	41.6
mAb17	0.09	48.30	0.19	64.89	54.2
mAb18	0.46	65.98	0.20	167.77	361.6
mAb19	0.46	52.18	0.19	6.41	121.9
mAb20	0.14	39.54	0.39	20.48	33.5
mAb21	0.10	40.07	0.80	14.00	54.8
mAb22	0.05	41.67	0.29	42.73	111.8
mAb23	0.11	54.96	0.33	49.29	39.7
mAb24	0.07	31.37	0.21	22.75	78.4
mAb25	0.32	55.76	0.32	27.73	104.1

CL: clearance from the central compartment, V1: volume of the central compartment, Q: inter-compartment distribution clearance, V2: volume of the peripheral compartment.

%RMSE: percent root mean square error.