Table 6.

Comparison of observed human PK parameters for individual mAbs and predicted human pharmacokinetic parameters determined by allometric scaling from hFcRnTg32 mouse.

mAb Number	Human PK	CL mL/h/kg	V1 mL/kg	Q mL/h/kg	V2 mL/kg	%RMSE
mAb18	Observed	0.46	66.01	0.19	166.77	114.4
mAb18	Predicted	0.45	37.34	0.51	56.69
mAb19	Observed	0.46	52.19	0.18	5.98	47.4
mAb19	Predicted	0.28	44.71	0.47	43.87
mAb20	Observed	0.14	39.56	0.38	20.51	66.6
mAb20	Predicted	0.14	57.46	0.61	36.56
mAb21	Observed	0.1	40.57	0.74	13.33	60.9
mAb21	Predicted	0.16	48.85	0.5	33.85
mAb22	Observed	0.05	41.7	0.29	42.72	83.1
mAb22	Predicted	0.1	51.2	0.8	42.49
mAb23	Observed	0.11	54.92	0.33	49.14	137.6
mAb23	Predicted	0.06	27.42	0.14	26.41
mAb24	Observed	0.07	31.39	0.21	22.72	24.3
mAb24	Predicted	0.08	24.93	0.22	28.29
mAb25	Observed	0.32	55.83	0.32	27.63	47.7
mAb25	Predicted	0.22	59.27	0.43	33.05

CL: clearance from the central compartment, V1: volume of the central compartment, Q: inter-compartment distribution clearance, V2: volume of the peripheral compartment.

%RMSE: percent root mean square error.