Table 7.

Comparison of observed human PK parameters for individual mAbs and predicted human pharmacokinetic parameters determined by allometric scaling from cynomolgus monkey.

mAb number	Human PK	CL mL/h/kg	V1 mL/kg	Q mL/h/kg	V2 mL/kg	%RMSE
mAb5	Observed	0.26	54.51	0.3	32.97	143.5
mAb5	Predicted	0.1	27.09	0.37	21.65	.
mAb7	Observed	0.21	57.02	0.69	16.43	43.5
mAb7	Predicted	0.28	58.88	0.83	70.31	.
mAb9	Observed	0.12	46.58	0.37	40.43	20.9
mAb9	Predicted	0.09	51.18	0.15	60.19	.
mAb10	Observed	0.07	34.62	0.25	24.38	36.7
mAb10	Predicted	0.11	46.63	0.17	27.36	.
mAb12	Observed	0.17	40.49	0.25	32.75	78.4
mAb12	Predicted	0.08	36.37	0.18	40.05	.
mAb14	Observed	0.18	38.52	0.31	15.72	50
mAb14	Predicted	0.29	40.93	0.34	18.56	.
mAb16	Observed	0.1	40.23	0.36	42.43	23.7
mAb16	Predicted	0.12	35.98	0.28	38.08	.
mAb17	Observed	0.09	48.3	0.19	64.89	135.2
mAb17	Predicted	0.07	38.09	0.44	13.91	.
mAb18	Observed	0.46	65.98	0.2	167.69	40
mAb18	Predicted	0.58	72.13	0.21	134.53	.
mAb19	Observed	0.46	52.18	0.19	6.39	67.9
mAb19	Predicted	0.26	56.93	0.02	15.17	.
mab20	Observed	0.14	39.53	0.39	20.51	55
mAb20	Predicted	0.1	42.3	0.3	33.58	.
mAb21	Observed	0.1	40.07	0.8	14	61.3
mAb21	Predicted	0.13	47.35	0.51	54.07	.
mAb22	Observed	0.05	41.67	0.29	42.73	146.5
mAb22	Predicted	0.26	54.23	0.57	61.06
mAb23	Observed	0.11	54.96	0.33	49.28	46.7
mAb23	Predicted	0.08	43.34	0.21	38.39	.
mAb24	Observed	0.07	31.37	0.21	22.75	31.9
mAb24	Predicted	0.08	35.94	0.14	28.98	.
mAb25	Observed	0.32	55.76	0.32	27.73	237.2
mAb25	Predicted	0.09	38.48	1.39	13.08	.

CL: clearance from the central compartment, V1: volume of the central compartment, Q: inter-compartment distribution clearance, V2: volume of the peripheral compartment.

%RMSE: percent root mean square error.