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. 2018 May 10;10(5):730–737. doi: 10.1080/19420862.2018.1463945

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© 2018 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 2. — SINEUP_-40+32 lncRNA transcripts boost mAb production for a variety of IgG4_s and enable stable mAb production yields. A. The chart reports the values of average productions for anti-CLDN1 IgG4 antibodies D10x, B9x and H9C1 in wild-type HEK293E cells, and in the HEK293ES_1, stably expressing the SINEUP_-40+32 lncRNA transcript. B. The chart shows the relative levels of the SINEUP_-40+32 transcripts (bottom) and the absolute yields of B9x antibody (top) after the indicated, consecutive passages of the HEK293ES_1 cells, stably expressing the lncRNA.