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Humanized variants of anti-TfR1 antibody with different TfR1 binding affinities. Sequence alignment of four humanized variants (AB402, AB403, AB404 and AB405) compared to the parent AB221 (anti-mTfR1) is shown and modifications made are highlighted. CDRs (dash lines) of both heavy and light chains remain the same. Cell-based binding assay shows reduced TfR1 binding affinity for AB404 and AB405 compared to AB221.
