Table 2.
Parameter | Unit | Cohort 1: Tg32 BM in Tg32 mice | Cohort 2: ko BM in Tg32 mice | Cohort 3: Tg32 BM in ko mice | Cohort 4: ko BM in ko mice* |
---|---|---|---|---|---|
CL | [mL/day/kg)] | 12.9 ± 2.5 a | 67.4 ± 18.1 b | 98.8 ± 17.0 c | 159 ± 24 |
Vc | [mL/kg] | 19.4 ± 3.7 | 20.1± 5.1 | 30.9 ± 10.2 | 50.5 ± 7.5 |
Vss | [mL/kg] | 112 ± 23 | 78.2 ± 19.9 | 102 ± 23 | 103 ± 22 |
t1/2 | [day] | 6.8 ± 1.1 a | 1.2 ± 0.2 d | 1.0 ± 0.3 e | 0.62 ± 0.10 |
AUC(0-inf) | [(µg·h)/mL] | 19300 ± 3860 | 3750 ± 840 | 2490 ± 425 | 1530 ± 224 |
Cmax | [µg/mL] | 510 ± 104 | 437 ± 72 | 334 ± 111 | 192 ± 29 |
n = 6; CL: clearance; Vc: central volume of distribution; Vss: volume of distribution at steady state; t1/2: apparent terminal half-life; AUC: area under the plasma concentration-time curve; Cmax: maximum plasma concentration.
Statistical comparisons by one-way ANOVA followed by Tukey's multiple comparison test:
p < 0.0001 versus cohorts 2, 3 and 4;
p < 0.01 versus cohort 3, p<0.001 versus cohort 4;
p < 0.001 versus cohort 4;
non-significant (ns) versus cohort 3, p<0.01 versus cohort 4;
p < 0.01 versus cohort 4.