Table 6.

Pharmacokinetic parameters of anti-TNP-specific IgG (mAb 1B7.11) following intraperitoneal administration at a dose of 4 mg/kg to B6.PL-Thy1a/CyJ (Thy1.1), and C57BL/6J FcRn knock-out (ko) mice as well as chimera thereof (from non-compartmental pharmacokinetic analysis of average concentration-time profiles of 10 to 12 mice/dose group) (Data from ¹⁴ ).

Parameter	Unit	Cohort 1 mice: Thy1.1 BM in Thy1.1 mice	Cohort 2 mice: ko BM in Thy1.1 mice	Cohort 3 mice: Thy1.1. BM in ko mice	Cohort 4 mice: ko BM in ko mice
CL/F	[mL/day/kg)]	14.6	66.5	60.1	100
Vz/F	[mL/kg]	174	274	225	200
t1/2	[day]	8.26	2.86	2.59	1.39
AUC(0-inf)	[(µg·h)/mL]	6580	1440	1600	960
Cmax	[µg/mL]	29.3	14.4	18.0	17.3