Table 6.
Parameter | Unit | Cohort 1 mice: Thy1.1 BM in Thy1.1 mice | Cohort 2 mice: ko BM in Thy1.1 mice | Cohort 3 mice: Thy1.1. BM in ko mice | Cohort 4 mice: ko BM in ko mice |
---|---|---|---|---|---|
CL/F | [mL/day/kg)] | 14.6 | 66.5 | 60.1 | 100 |
Vz/F | [mL/kg] | 174 | 274 | 225 | 200 |
t1/2 | [day] | 8.26 | 2.86 | 2.59 | 1.39 |
AUC(0-inf) | [(µg·h)/mL] | 6580 | 1440 | 1600 | 960 |
Cmax | [µg/mL] | 29.3 | 14.4 | 18.0 | 17.3 |